![]() ![]() In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Overexpressed in cancers of the ovary, colon and liver. In premalignant cancer expression is not restricted to the cript base. Expressed at the base of crypts in colonic and small mucosa stem cells. ![]() Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |